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HR+/HER2-Early Breast Cancer2026

Survival Analysis of the WSG TP-II Trial: Neoadjuvant Trastuzumab and Pertuzumab Plus Endocrine Therapy Versus Chemotherapy in Hormone Receptor-Positive/Human Epidermal Growth Factor Receptor 2-Positive Early Breast Cancer.

Gluz O et al. J Clin Oncol. 2026

HR+/HER2-Early Breast Cancer2026

Clinical and molecular biomarkers for prediction of endocrine response after short preoperative endocrine therapy in the WSG ADAPT-HR+/HER2- and ADAPTcycle trials (N=7914).

Gluz O et al. Ann Oncol. 2026

HR+/HER2-both2026

An Analytical Framework Characterizes the Biological Processes that Shape Copy Number-Based Genome Instability Patterns in Breast Cancer.

Wong H et al. Cancer Res. 2026

HER2+ (HR-)both2026

TQB2440 compared with reference pertuzumab for HER2-positive, ER/PgR-negative, early or locally advanced breast cancer: a multicenter, randomized, double-blind, parallel-controlled, phase III equivalence trial.

Wang S et al. ESMO Open. 2026

HR+/HER2-Advanced / Metastatic Breast Cancer2026

VIKTORIA-1 Trial of Gedatolisib Plus Fulvestrant With or Without Palbociclib in Hormone Receptor-Positive/HER2-/PIK3CA Wild-Type Advanced Breast Cancer.

Hurvitz SA et al. J Clin Oncol. 2026

HR+/HER2-Early Breast Cancer2026

Molecular profile of residual triple-negative breast cancer: opportunities for post-neoadjuvant therapeutic interventions.

van den Ende NS et al. NPJ Breast Cancer. 2026

HR+/HER2-Advanced / Metastatic Breast Cancer2026

A phase IV prospective study of efficacy and safety of ribociclib and letrozole as first-line therapy in older women (≥70 years) with hormone receptor-positive HER2-negative advanced breast cancer: the RibOB study.

Van Houdt M et al. ESMO Open. 2026

HR+/HER2-Early Breast Cancer2026

Extended Endocrine Therapy Following 5 Years of Adjuvant Luteinizing Hormone-Releasing Hormone Agonist in Premenopausal Patients With Node-Positive, Hormone Receptor-Positive Breast Cancer: A Cohort Study.

Valenza C et al. J Clin Oncol. 2026

HER2+ (HR-)Advanced / Metastatic Breast Cancer2026

Analysis of UGT1A1 germline variants in patients with advanced breast cancer treated with trastuzumab-deruxtecan: results from the PROCURE Project.

Sánchez-Bayona R et al. ESMO Open. 2026

TNBCAdvanced / Metastatic Breast Cancer2026

Datopotamab deruxtecan in patients with untreated, advanced triple-negative breast cancer (TROPION-Breast02): a randomised, open-label, international, phase III trial.

Dent R et al. Ann Oncol. 2026

HR+/HER2-Early Breast Cancer2026

TRADE: a phase II trial to assess the tolerability of abemaciclib dose escalation in early-stage HR-positive/HER2-negative breast cancer.

Mayer EL et al. Ann Oncol. 2026

TNBCAdvanced / Metastatic Breast Cancer2026

Preclinical characterization and phase 1 results of TQB2102, a first-in-class HER2 biparatopic antibody-drug conjugate, in patients with advanced solid tumors.

Ruan DY et al. Ann Oncol. 2026

TNBCAdvanced / Metastatic Breast Cancer2026

Sacituzumab Govitecan plus Pembrolizumab for Advanced Triple-Negative Breast Cancer.

Tolaney SM et al. N Engl J Med. 2026

HER2+ (HR-)Advanced / Metastatic Breast Cancer2026

Molecular imaging of tucatinib-induced cellular and TME changes in preclinical models of HER2 + breast cancer.

Song PN et al. Breast Cancer Res Treat. 2026

HR+/HER2-both2026

TLR7 signature of tumour innervation reveals two distinct pathways of triple-negative breast cancer progression.

Wang DY et al. Br J Cancer. 2026

genomicAdvanced / Metastatic Breast Cancer2026

TBCRC 048 (Olaparib Expanded) Expansion Cohorts: Phase II Study of Olaparib Monotherapy for Patients With Metastatic Breast Cancer With Germline Mutations in PALB2 or Somatic Mutations in BRCA1 or BRCA2.

Tung NM et al. J Clin Oncol. 2026

HR+/HER2-Advanced / Metastatic Breast Cancer2026

TBCRC 035: randomized phase II pharmacodynamic study of standard and reduced-dose palbociclib with endocrine therapy in hormone receptor (HR)-positive previously treated metastatic breast cancer.

Jacob S et al. ESMO Open. 2026

generalEarly Breast Cancer2026

Adjuvant capecitabine in women with triple-negative breast cancer with residual disease after carboplatin-containing neoadjuvant chemotherapy.

Tavares GM et al. Breast Cancer Res Treat. 2026

HR+/HER2-Advanced / Metastatic Breast Cancer2026

Single-cell transcriptomics reveals immune landscape dynamics in metastatic hormone receptor-positive breast cancer treated with abemaciclib and endocrine therapy.

Strawser CH et al. Clin Cancer Res. 2026

HR+/HER2-both2026

Change in practice patterns over time for endocrine therapy and radiation therapy in women with breast cancer age 65 and older.

Stickland A et al. Breast Cancer Res Treat. 2026

TNBCEarly Breast Cancer2026

Impact of immune-related adverse events on response to neoadjuvant chemoimmunotherapy in triple-negative breast cancer: a single-institution retrospective study.

Sterpi M et al. Breast Cancer Res Treat. 2026

HER2+ (HR-)Advanced / Metastatic Breast Cancer2026

Real-world outcomes of reduced-dose versus standard-dose antibody drug conjugates in metastatic breast cancer: a retrospective cohort study.

Stabellini N et al. Breast Cancer Res Treat. 2026

HR+/HER2-Early Breast Cancer2026

Neoadjuvant therapy with an aromatase inhibitor and durvalumab in postmenopausal patients with hormone receptor-positive breast cancer.

Soyano Muller AE et al. Breast Cancer Res Treat. 2026

HR+/HER2-Advanced / Metastatic Breast Cancer2026

Genomic Determinants of Response to Alpelisib Plus Fulvestrant in the SOLAR-1 Trial.

Juric D et al. Ann Oncol. 2026

HR+/HER2-Early Breast Cancer2026

Final outcomes of the SOFT and TEXT phase III trials in premenopausal hormone receptor-positive early breast cancer.

Francis PA et al. Ann Oncol. 2026

HR+/HER2-Early Breast Cancer2026

Combination of predicted sensitivity to endocrine therapy (SET2,3 index) and the recurrence score® in node-positive breast cancer: Independent validation in the PACS-01 trial.

Penault-Llorca F et al. Eur J Cancer. 2026

HR+/HER2-both2026

Pharmacodynamics of Camizestrant Treatment in Postmenopausal Women With Estrogen Receptor-Positive, Human Epidermal Growth Factor Receptor 2-Negative Primary Breast Cancer: Results From the Randomized, Presurgical SERENA-3 Study.

Robertson JFR et al. J Clin Oncol. 2026

TNBCboth2026

The SDC1-ENO1 Axis in Cancer-Associated Fibroblasts Generates a Lactate-Rich Microenvironment That Drives Tumor Radioresistance.

Hou X et al. Cancer Res. 2026

HR+/HER2-Advanced / Metastatic Breast Cancer2026

Durvalumab Plus Paclitaxel, with or without Capivasertib or Oleclumab, in Patients with Locally Advanced/Metastatic Triple-Negative Breast Cancer.

Schmid P et al. Clin Cancer Res. 2026

TNBCAdvanced / Metastatic Breast Cancer2026

Sacituzumab govitecan in patients with metastatic breast cancer: pooled safety analysis of data from patients in North America, Europe, and Asia.

Rugo HS et al. ESMO Open. 2026

HR+/HER2-both2026

Emerging Strategies to Inhibit the G1/S Transition for Cancer Therapy.

Rubin SM et al. Cancer Res. 2026

generalEarly Breast Cancer2026

Adjuvant Epirubicin Plus Cyclophosphamide Followed by Taxanes With or Without Carboplatin in Early-Stage Triple-Negative Breast Cancer (RJBC 1501): A Randomized Phase III Trial.

Chen X et al. J Clin Oncol. 2026

generalEarly Breast Cancer2026

Long-term outcomes in triple-negative breast cancer after a pathologic complete response: does the type of neoadjuvant therapy matter?

Ravani LV et al. Breast Cancer Res Treat. 2026

HR+/HER2-Advanced / Metastatic Breast Cancer2026

Exploratory analysis of PTEN deficiency by immunohistochemistry from the Phase III CAPItello-291 trial.

Jhaveri K et al. Clin Cancer Res. 2026

HR+/HER2-Early Breast Cancer2026

Updated Results of the POSITIVE (Pregnancy Outcome and Safety of Interrupting Therapy for Women with Endocrine Responsive Breast Cancer) Trial.

Pagani O et al. Ann Oncol. 2026

HR+/HER2-Advanced / Metastatic Breast Cancer2026

Expert recommendations for PIK3CA testing in HR+/HER2- locally advanced and metastatic breast cancer.

Marchiò C et al. NPJ Breast Cancer. 2026

HR+/HER2-Advanced / Metastatic Breast Cancer2026

Alpelisib and Fulvestrant in PIK3CA-mutated hormone receptor-positive HER2-negative advanced breast cancer included in the German PRAEGNANT trial.

Hörner M et al. Breast Cancer Res Treat. 2026

HR+/HER2-both2026

PIK3CA mutations and first-line outcomes in endocrine-resistant HR+/HER2- metastatic breast cancer: A multicentric real-world study.

Dieci MV et al. Eur J Cancer. 2026

HR+/HER2-both2026

PI3Kα Inhibitor and Degrader Inavolisib Can Co-opt FGFR2 to Enhance Responses in Patients with PIK3CA-Mutated Solid Tumors and in Preclinical Models.

Juric D et al. Clin Cancer Res. 2026

HR+/HER2-Advanced / Metastatic Breast Cancer2026

PI3K Inhibition in Combination with Tamoxifen in Patients with Metastatic HR+/HER2- Breast Cancer: Clinical and Circulating Tumor DNA Results.

Voorthuis RAB et al. Clin Cancer Res. 2026

HR+/HER2-Advanced / Metastatic Breast Cancer2026

Tucatinib Gives PFS Boost for Metastatic Breast Cancer.

Cancer Discov. 2026

HER2+ (HR-)both2026

Potency and safety of novel [225Ac]Ac-labeled pertuzumab-PEGylated emtansine drug conjugate against HER2-positive breast cancer.

Pougoue Ketchemen J et al. Br J Cancer. 2026

generalEarly Breast Cancer2026

Clinical Validation of Digital PCR-Based ctDNA Detection for Risk Stratification in Residual Triple-Negative Breast Cancer: TRICIA Trial Results.

Roseshter T et al. Clin Cancer Res. 2026

HR+/HER2+ (Triple Positive)Advanced / Metastatic Breast Cancer2026

PATINA — Palbociclib + Anti-HER2 Therapy + ET in HR+/HER2+ MBC

Metzger O et al. NEJM. 2026

genomicAdvanced / Metastatic Breast Cancer2026

PARP inhibition with olaparib and talazoparib for HER2-negative advanced breast cancer-Results from the prospective PRAEGNANT registry.

Hörner M et al. NPJ Breast Cancer. 2026

HR+/HER2-both2026

Simultaneous inhibition of PARP/AKT to intercept nascent BRCA1/2mut breast tumors.

Wang L et al. NPJ Breast Cancer. 2026

generalboth2026

Clonal Hematopoiesis and Risk of Trastuzumab-Related Cardiotoxic Effects.

Park CS et al. JAMA Oncol. 2026

generalAdvanced / Metastatic Breast Cancer2026

OPTIMAL: A Multinational Phase III Study of Oral Paclitaxel (DHP107) versus Intravenous Weekly Paclitaxel in HER2-Negative Recurrent or Metastatic Breast Cancer.

Xu B et al. Ann Oncol. 2026

generalAdvanced / Metastatic Breast Cancer2026

OPERA: a phase II study of DHP107 (oral paclitaxel) versus intravenous paclitaxel in patients with HER2-negative recurrent or metastatic breast cancer.

Rugo HS et al. Breast Cancer Res Treat. 2026

HR+/HER2-Early Breast Cancer2026

Comparison of suboptimal versus adequate ovarian function suppression in premenopausal women with early breast cancer treated with adjuvant endocrine therapy: An exploratory analysis of two prospective studies.

Nardin S et al. Eur J Cancer. 2026