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202621 papers

GeneralAdvanced/Metastatic (IV)2026

Tiragolumab plus atezolizumab and chemotherapy as first-line treatment for patients with unresectable oesophageal squamous cell carcinoma (SKYSCRAPER-08): a randomised, double-blind, placebo-controlled, phase 3 trial.

Hsu CH et al. Lancet Oncol. 2026

GeneralResectable (I-III)2026

PET/CT-Guided Neoadjuvant Tislelizumab plus Chemotherapy/Chemoradiotherapy for Resectable Esophageal Squamous Cell Carcinoma: RATIONALE-213 Final Analysis.

Yang Y et al. Clin Cancer Res. 2026

GeneralAll Stages2026

Prolonged Time to Surgery in Patients With Residual Disease After Neoadjuvant Chemoradiotherapy for Esophageal Cancer.

Overtoom HCG et al. Ann Surg. 2026

GeneralAdvanced/Metastatic (IV)2026

First-line tiragolumab plus atezolizumab and chemotherapy in patients with previously untreated, locally advanced unresectable or metastatic oesophageal cancer (MORPHEUS-EC): a randomised, open-label, phase 1b/2 trial.

Sun JM et al. Lancet Oncol. 2026

HER2-positiveAll Stages2026

Trastuzumab Rezetecan in Human Epidermal Growth Factor Receptor 2-Expressing Advanced Gastric Cancer or Gastroesophageal Junction Adenocarcinoma and Colorectal Cancer: A Multicenter, Open-Label, Phase I Trial.

Liu T et al. J Clin Oncol. 2026

GeneralAll Stages2026

Integrating lymphovascular invasion and ypTNM staging system for esophageal squamous cell carcinoma undergoing neoadjuvant chemoradiotherapy and surgery: a multi-institutional analysis.

Liu S et al. Br J Cancer. 2026

GeneralResectable (I-III)2026

Is pathological complete response a surrogate for overall survival in neoadjuvant clinical trials for gastroesophageal adenocarcinoma?

Leite LF et al. Eur J Cancer. 2026

GeneralAll Stages2026

Association between effectiveness of treatment with curative intent and outcomes of first-line systemic therapy in metachronous metastatic gastroesophageal adenocarcinoma.

Kamp D et al. Br J Cancer. 2026

ImmunotherapyAdvanced/Metastatic (IV)2026

Final overall survival analysis and exploratory biomarker study from JUPITER-06: a randomized phase III trial of toripalimab plus chemotherapy in advanced esophageal squamous-cell carcinoma.

Chen YX et al. Ann Oncol. 2026

ImmunotherapyAdvanced/Metastatic (IV)2026

Nivolumab plus chemotherapy as first-line treatment for advanced gastric, gastroesophageal junction, and esophageal adenocarcinoma: 5-year follow-up results from CheckMate 649.

Janjigian YY et al. Ann Oncol. 2026

GeneralAll Stages2026

ISDE guidelines on the management of cT2N0 esophageal cancer.

Kohn GP et al. Dis Esophagus. 2026

GeneralResectable (I-III)2026

Prognostic Impact of Postoperative Complications After Neoadjuvant Therapy Followed by Esophagectomy for Esophageal Cancer: An Exploratory Analysis of Phase III Trial JCOG1109.

Booka E et al. Ann Surg. 2026

GeneralResectable (I-III)2026

Health-related quality of life comparing standard and prolonged time-to-surgery after neoadjuvant chemoradiotherapy for esophageal cancer: results from the multicenter, randomized, controlled NeoRes II trial.

Holmén A et al. Dis Esophagus. 2026

ImmunotherapyAdvanced/Metastatic (IV)2026

Tislelizumab Combined With Induction Chemotherapy and Concurrent Chemoradiotherapy in Locally Advanced Esophageal Squamous Cell Carcinoma: A Multicenter, Randomized, Phase II Trial (EC-CRT-002).

Chen B et al. J Clin Oncol. 2026

ImmunotherapyResectable (I-III)2026

Neoadjuvant immunochemoradiotherapy with nivolumab, paclitaxel, and cisplatin followed by esophagectomy for locally advanced esophageal squamous cell carcinoma.

Huang TC et al. Br J Cancer. 2026

HER2-positiveAdvanced/Metastatic (IV)2026

Zanidatamab with and without Tislelizumab in HER2-Positive Gastroesophageal Cancer.

Shitara K et al. N Engl J Med. 2026

GeneralResectable (I-III)2026

Pathological Outcomes After Uncertain Response to Neoadjuvant Chemoradiotherapy in Esophageal Cancer.

Gangaram Panday SSG et al. Ann Surg. 2026

GeneralResectable (I-III)2026

Patient-derived cancer organoids to tailor personalized treatment strategies in upper gastrointestinal malignancies.

Franken IA et al. Dis Esophagus. 2026

GeneralResectable (I-III)2026

Does perioperative FLOT increase cure rates in resectable esophageal adenocarcinoma? A mixture cure model analysis.

Mateos L et al. Br J Cancer. 2026

ImmunotherapyAdvanced/Metastatic (IV)2026

Immunotherapy and Targeted Therapy for Advanced Gastroesophageal Cancer: ASCO Guideline Update.

Shah MA et al. J Clin Oncol. 2026

GeneralResectable (I-III)2026

Prognostic factors for paraconduit hernia in adult patients post-esophagectomy for cancer: a systematic review.

Abdel Fattah AR et al. Dis Esophagus. 2026

202529 papers

GeneralAll Stages2025

Adjuvant immunotherapy in esophageal squamous cell carcinoma after radiotherapy: retrospective multicentric survival analysis.

Zeng W et al. Dis Esophagus. 2025

GeneralAll Stages2025

Prognostic impact of recurrent laryngeal nerve lymph node metastatic status in thoracic esophageal squamous cell carcinoma.

Yang P et al. Dis Esophagus. 2025

GeneralAll Stages2025

Recurrence patterns following neoadjuvant chemotherapy combined with immunotherapy for esophageal squamous cell carcinoma.

Wang M et al. Dis Esophagus. 2025

GeneralResectable (I-III)2025

Cancer-associated fibroblasts are associated with neo-adjuvant treatment response in oesophageal adenocarcinoma.

Walker RC et al. Br J Cancer. 2025

GeneralAll Stages2025

TFOX versus FOLFOX in first-line treatment of patients with advanced HER2-negative gastric or gastro-oesophageal junction adenocarcinoma (PRODIGE 51- FFCD-GASTFOX): an open-label, multicentre, randomised, phase 3 trial.

Zaanan A et al. Lancet Oncol. 2025

GeneralResectable (I-III)2025

Gastric conduit necrosis following esophagectomy: is conduit salvage feasible?

Tankel J et al. Dis Esophagus. 2025

ImmunotherapyAdvanced/Metastatic (IV)2025

Clinical outcomes of pembrolizumab plus chemotherapy for postoperative recurrent esophageal squamous cell carcinoma.

Sugase T et al. Dis Esophagus. 2025

HER2-positiveAdvanced/Metastatic (IV)2025

Trastuzumab Deruxtecan or Ramucirumab plus Paclitaxel in Gastric Cancer.

Shitara K et al. N Engl J Med. 2025

GeneralResectable (I-III)2025

Neoadjuvant chemoradiotherapy followed by active surveillance versus standard surgery for oesophageal cancer (SANO trial): a multicentre, stepped-wedge, cluster-randomised, non-inferiority, phase 3 trial.

van der Wilk BJ et al. Lancet Oncol. 2025

GeneralAll Stages2025

Neoadjuvant chemoimmunotherapy cycles in locally advanced Esophageal squamous cell carcinoma: a retrospective comparison of three versus two cycles.

Rusidanmu A et al. Dis Esophagus. 2025

GeneralAdvanced/Metastatic (IV)2025

Regorafenib combined with irinotecan as second-line treatment in metastatic gastro-oesophageal adenocarcinomas: results of PRODIGE 58-UCGI35-REGIRI Unicancer randomised phase II study.

Samalin E et al. ESMO Open. 2025

GeneralResectable (I-III)2025

Proposal of New ypStage Grouping System for Esophageal Squamous Cell Carcinoma Patients who Underwent Neoadjuvant Chemoradiotherapy followed by Surgery.

Park SY et al. Ann Surg. 2025

ImmunotherapyAdvanced/Metastatic (IV)2025

NOTCH1 Mutation and Survival Analysis of Tislelizumab in Advanced or Metastatic Esophageal Squamous Cell Carcinoma: A Biomarker Analysis From the Randomized, Phase III, RATIONALE-302 Trial.

Lu Z et al. J Clin Oncol. 2025

GeneralAll Stages2025

Oncogenic NFE2L2 mutations in plasma ctDNA and tumors are predictors and prognosticators of chemoradiation therapy in resectable esophageal squamous cell carcinoma.

Ko JM et al. Br J Cancer. 2025

GeneralAll Stages2025

Three-field lymph node dissection subsequent to neoadjuvant concurrent chemoradiotherapy in esophageal cancer.

Na B et al. Dis Esophagus. 2025

GeneralAll Stages2025

Causes of death in locally advanced esophageal cancer undergoing neoadjuvant chemotherapy and neoadjuvant chemoradiotherapy: a retrospective cohort study.

Liu D et al. Dis Esophagus. 2025

GeneralAll Stages2025

Incomplete neoadjuvant chemo(radio)therapy negatively impacts pathological response and overall survival in locally advanced esophageal cancer.

Kamp D et al. Eur J Cancer. 2025

GeneralAdvanced/Metastatic (IV)2025

Toward standardization in esophageal cancer surgery: patterns of practice across high-volume European centers.

Jones DG et al. Dis Esophagus. 2025

GeneralResectable (I-III)2025

Perioperative Durvalumab in Gastric and Gastroesophageal Junction Cancer.

Janjigian YY et al. N Engl J Med. 2025

GeneralAdvanced/Metastatic (IV)2025

Domvanalimab and zimberelimab in advanced gastric, gastroesophageal junction or esophageal cancer: a phase 2 trial.

Janjigian YY et al. Nat Med. 2025

GeneralAdvanced/Metastatic (IV)2025

Nal-IRI/LV5-FU versus paclitaxel as second-line therapy in patients with metastatic esophageal squamous cell carcinoma (PRODIGE 62-FFCD 1701-OESIRI).

Tougeron D et al. Eur J Cancer. 2025

GeneralResectable (I-III)2025

Recurrence-free Survival as a Surrogate Endpoint for Overall Survival in Resectable Esophageal Cancer: Integrated Analysis of Individual Patient Data From Phase III Trials.

Okui J et al. Ann Surg. 2025

GeneralAll Stages2025

Pembrolizumab Plus Chemotherapy Versus Chemotherapy as Perioperative Therapy in Locally Advanced Gastric and Gastroesophageal Junction Cancer: Final Analysis of the Randomized, Phase III KEYNOTE-585 Study.

Shitara K et al. J Clin Oncol. 2025

ImmunotherapyAdvanced/Metastatic (IV)2025

Pembrolizumab plus chemotherapy versus chemotherapy for advanced esophageal cancer: 5-year extended follow-up for the randomized phase III KEYNOTE-590 study.

Metges JP et al. ESMO Open. 2025

GeneralAdvanced/Metastatic (IV)2025

Recurrence Patterns of Esophageal Adenocarcinoma in the Phase III ESOPEC Trial Comparing Perioperative Chemotherapy With Preoperative Chemoradiotherapy.

Hoeppner J et al. J Clin Oncol. 2025

ImmunotherapyAdvanced/Metastatic (IV)2025

Lenvatinib Plus Pembrolizumab and Chemotherapy Versus Chemotherapy in Advanced Metastatic Gastroesophageal Adenocarcinoma: The Phase III, Randomized LEAP-015 Study.

Shitara K et al. J Clin Oncol. 2025

ImmunotherapyAdvanced/Metastatic (IV)2025

Phase II Study (NO LIMIT, WJOG13320G) of First-Line Nivolumab Plus Low-Dose Ipilimumab for Microsatellite Instability-High Advanced Gastric or Esophagogastric Junction Cancer.

Kawakami H et al. J Clin Oncol. 2025

GeneralAdvanced/Metastatic (IV)2025

Treatment strategy involving docetaxel plus cisplatin and 5-fluorouracil followed by conversion surgery for locally advanced unresectable/borderline resectable esophageal squamous cell carcinoma.

Igaue S et al. Dis Esophagus. 2025

GeneralAdvanced/Metastatic (IV)2025

Perioperative Chemotherapy or Preoperative Chemoradiotherapy in Esophageal Cancer.

Hoeppner J et al. N Engl J Med. 2025