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22
1990
27
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23
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41
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1995
43
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55
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2000
68
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87
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2005
136
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148
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2010
174
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201
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217
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2015
196
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2020
242
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2025
97
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202637 papers

GeneralAll Stages2026

Watch-and-Wait Policy to Defer Defunctioning Stoma After Low Anterior Resection: Preliminary Results From the Safe Anastomosis Project (KNUCRC-25CP02).

Kim HJ et al. Dis Colon Rectum. 2026

GeneralEarly (I-III)2026

Dynamic ctDNA Monitoring Guides Early Treatment Intensification in Locally Advanced Rectal Cancer Undergoing Neoadjuvant Chemotherapy.

Shen Y et al. Clin Cancer Res. 2026

GeneralEarly (I-III)2026

Organ preservation with total neoadjuvant therapy in early-stage rectal cancer: A statewide analysis.

Bunjo Z et al. Colorectal Dis. 2026

MSI-H/dMMRAll Stages2026

Tumour immune contexture and immune evasion in sporadic and Lynch syndrome-associated microsatellite unstable colorectal cancers.

Martin S et al. Br J Cancer. 2026

GeneralEarly (I-III)2026

Late Anastomotic Leakage After Rectal Cancer Surgery: Incidence and Differential Risk Factors.

Kim HK et al. Dis Colon Rectum. 2026

GeneralAll Stages2026

Complications After Rectal Cancer Surgery: Do Female Patients Fare Better? A Retrospective, Matched Cohort Analysis.

Damanakis AI et al. Dis Colon Rectum. 2026

Biomarker/ctDNAEarly (I-III)2026

Preoperative Identification of Lymph Node Metastasis in Colorectal Cancer Using Noninvasive Circulating Tumor DNA Methylation Signatures: Results From a Prospective Study.

Ji H et al. Dis Colon Rectum. 2026

GeneralEarly (I-III)2026

Impact of Obesity on Postoperative Outcomes in Transanal Total Mesorectal Excision for Rectal Cancer.

Zewde MG et al. Dis Colon Rectum. 2026

GeneralAdvanced/Metastatic (IV)2026

eIF3i facilitates NELFCD translation to promote metastasis via regulating EMT and invadopodia.

Huang Q et al. Br J Cancer. 2026

GeneralAll Stages2026

A standardised approach to the pathological dissection and reporting of pelvic exenteration specimens: Recommendations from the UK Pelvic Exenteration Network (UKPEN).

Aldridge J et al. Colorectal Dis. 2026

RAS wild-typeAdvanced/Metastatic (IV)2026

Fulzerasib plus cetuximab in first-line KRASG12C-mutated non-small-cell lung cancer (KROCUS): a single-arm, multicentre, phase 1b/2 trial.

Gregorc V et al. Lancet Oncol. 2026

GeneralEarly (I-III)2026

Nonoperative Management for Rectal Cancer: A Qualitative Study of Patient Perceptions, Priorities, Barriers, and Facilitators to Surveillance.

Hilty Chu BK et al. Dis Colon Rectum. 2026

GeneralAdvanced/Metastatic (IV)2026

Young adults undergoing anterior resection for colorectal cancer experience fewer medical complications but a comparable risk of anastomotic leak.

Rudasill SE et al. Colorectal Dis. 2026

BRAF V600EAdvanced/Metastatic (IV)2026

Gastric and Rectal Administration of Encorafenib with Targeted Chemotherapy against BRAF V600E-Mutant Rectal Cancer with Bowel Obstruction.

Funk MA et al. Oncologist. 2026

GeneralEarly (I-III)2026

Atezolizumab plus FOLFOX for Stage III Mismatch Repair-Deficient Colon Cancer.

Sinicrope FA et al. N Engl J Med. 2026

GeneralAll Stages2026

Safety and feasibility of S-1 after capecitabine-induced toxicity in the adjuvant treatment of colon cancer patients: A population-based real-world study.

Ghedri A et al. Eur J Cancer. 2026

GeneralAdvanced/Metastatic (IV)2026

Clinical outcomes of trifluridine/tipiracil plus bevacizumab versus trifluridine/tipiracil or regorafenib in metastatic colorectal cancer: a multicenter cohort study.

Moik F et al. ESMO Open. 2026

GeneralAdvanced/Metastatic (IV)2026

The Randomized Phase 2 ARC-9 Study of Etrumadenant-Based Therapy vs Regorafenib in Patients with Previously Treated Metastatic Colorectal Cancer.

Cecchini M et al. Clin Cancer Res. 2026

GeneralAdvanced/Metastatic (IV)2026

Randomized phase II study of FOLFIRI plus ramucirumab versus FOLFOXIRI plus ramucirumab as first-line treatment for metastatic colorectal cancer: WJOG9216G (RECAST).

Kito Y et al. Eur J Cancer. 2026

GeneralEarly (I-III)2026

Differential Immunologic Effects of Short-Course and Long-Course Radiotherapy in Locally Advanced Rectal Cancer.

Hillson LVS et al. Clin Cancer Res. 2026

MSI-H/dMMRAdvanced/Metastatic (IV)2026

Acquired High Tumor Mutational Burden and Activity of Immunotherapy after Targeted Therapy in Microsatellite Stable Colorectal Cancer.

Yeh C et al. Clin Cancer Res. 2026

GeneralAdvanced/Metastatic (IV)2026

Distribution and prognostic value of macrophages in colorectal cancer and adjacent mucosa in patient stages I-III vs IV.

Ye WJ et al. World J Gastroenterol. 2026

Biomarker/ctDNAEarly (I-III)2026

Cancer-associated fibroblast signature and SMAD4 mutation in resistance to adjuvant chemotherapy in stage III colon cancer patients.

Franken IA et al. Eur J Cancer. 2026

MSI-H/dMMRAll Stages2026

Challenges of neoadjuvant immunotherapy in mismatch repair-deficient/microsatellite-unstable localized colon cancer patients.

Karoui M et al. ESMO Open. 2026

GeneralAll Stages2026

Long-term outcomes following a pathological complete response at the primary tumor site after preoperative therapy in metastatic colorectal cancer.

Luo D et al. Oncologist. 2026

RAS mutantAll Stages2026

Emerging landscape of KRAS inhibitors in cancer treatment.

Riedl JM et al. Cancer Cell. 2026

RAS wild-typeAll Stages2026

TP53 mutation is associated with improved disease control in patients with advanced RAS wild-type colorectal adenocarcinoma treated with cetuximab and pembrolizumab.

Fountzilas C et al. Int J Cancer. 2026

GeneralEarly (I-III)2026

Disruptive Analysis of Total Neoadjuvant Therapy in Locally Advanced Rectal Cancer: Clinical and Therapeutic Distinctions Between Low- and Mid-Rectal Cancers.

Noiret B et al. J Clin Oncol. 2026

MSI-H/dMMREarly (I-III)2026

Consensus guidance of immune checkpoint inhibitors in locally advanced rectal cancer.

Yang Z et al. Gut. 2026

HER2 amplifiedAll Stages2026

Trastuzumab Rezetecan in Human Epidermal Growth Factor Receptor 2-Expressing Advanced Gastric Cancer or Gastroesophageal Junction Adenocarcinoma and Colorectal Cancer: A Multicenter, Open-Label, Phase I Trial.

Liu T et al. J Clin Oncol. 2026

RAS wild-typeAdvanced/Metastatic (IV)2026

Deep Learning-Derived Sarcopenia Marker Predicts Benefit from Anti-EGFR Therapy in Patients with RAS Wild-type Metastatic Colorectal Cancer.

Keyl J et al. Clin Cancer Res. 2026

MSI-H/dMMRAdvanced/Metastatic (IV)2026

Multiagent Combo Bests Immunotherapy Alone against Colorectal Cancer.

Cancer Discov. 2026

RAS wild-typeAdvanced/Metastatic (IV)2026

ctDNA Detection with Low-Pass Whole-Genome Bisulfite Sequencing in RAS Wild-Type Metastatic Colorectal Cancer: An Exploratory Objective of the VALENTINO Trial.

Manca P et al. Clin Cancer Res. 2026

GeneralEarly (I-III)2026

Three Versus 6 Months of Adjuvant Oxaliplatin-Fluoropyrimidine Chemotherapy for Colorectal Cancer: Final Results of SCOT-An International, Randomized, Phase III, Noninferiority Trial.

Iveson T et al. J Clin Oncol. 2026

GeneralEarly (I-III)2026

Rectal Cancer in the Elderly: To Operate or Not to Operate? A Nationwide Retrospective Study of the Italian Society of Surgical Oncology-Colorectal Cancer Network Collaborative Group.

Reddavid R et al. Dis Colon Rectum. 2026

GeneralEarly (I-III)2026

Targeting the DNA damage response prevents regrowth of colorectal peritoneal metastasis-derived organoids following treatment with mitomycin C.

van Megesen K et al. Br J Cancer. 2026

GeneralEarly (I-III)2026

Randomized Parallel-Group Phase II Study (NEOTERIC) of Atezolizumab With or Without Tiragolumab After Neoadjuvant Chemoradiotherapy in Locally Advanced Rectal Cancer.

Tang W et al. J Clin Oncol. 2026

20255 papers

MSI-H/dMMRAll Stages2025

The landscape of primary mismatch repair deficient gliomas in children, adolescents, and young adults: a multi-cohort study.

Negm L et al. Lancet Oncol. 2025

MSI-H/dMMRAdvanced/Metastatic (IV)2025

Pembrolizumab versus chemotherapy in microsatellite instability-high or mismatch repair-deficient metastatic colorectal cancer: 5-year follow-up from the randomized phase III KEYNOTE-177 study.

André T et al. Ann Oncol. 2025

MSI-H/dMMRAll Stages2025

Sarcomas developed in patients with Lynch Syndrome are enriched in pleomorphic soft-tissue sarcomas and are sensitive to immunotherapy.

Poumeaud F et al. Eur J Cancer. 2025

GeneralAll Stages2025

Features of Lateral Pelvic Lymph Nodes Associated With Pathological Involvement After Total Neoadjuvant Therapy in Patients Undergoing Lateral Pelvic Lymph Node Dissection.

Noguchi T et al. Dis Colon Rectum. 2025

GeneralEarly (I-III)2025

Correlation Between Grade of Clinical Response to Neoadjuvant Therapy for Rectal Cancer and Oncologic Outcomes in the Era of Watch-and-Wait.

Rosen RY et al. Dis Colon Rectum. 2025

20248 papers

MSI-H/dMMRAdvanced/Metastatic (IV)2024

Duration of immunotherapy in dMMR/MSI-H metastatic colorectal cancer patients.

Margalit O et al. Eur J Cancer. 2024

MSI-H/dMMRAdvanced/Metastatic (IV)2024

Advancements in immunotherapy for colorectal cancer treatment: a comprehensive review of strategies, challenges, and future prospective.

Kaviyarasan V et al. Int J Colorectal Dis. 2024

MSI-H/dMMRAll Stages2024

Neoadjuvant nivolumab and relatlimab in locally advanced MMR-deficient colon cancer: a phase 2 trial.

de Gooyer PGM et al. Nat Med. 2024

GeneralAll Stages2024

Tailored resection for persistent extramural vascular invasion in locally advanced rectal cancers.

Ballal DS et al. Colorectal Dis. 2024

MSI-H/dMMRAdvanced/Metastatic (IV)2024

Genomic profiles and their associations with microsatellite instability status, tumor mutational burden, and programmed death ligand 1 expression in Chinese patients with colorectal cancer.

Luo B et al. J Gastrointest Oncol. 2024

MSI-H/dMMRAdvanced/Metastatic (IV)2024

Liver metastases and peritoneal metastases and response to checkpoint inhibitors in metastatic colorectal cancer with microsatellite instability.

Fakih M et al. Oncologist. 2024

MSI-H/dMMRAdvanced/Metastatic (IV)2024

Nivolumab plus Ipilimumab in Microsatellite-Instability-High Metastatic Colorectal Cancer.

Andre T et al. N Engl J Med. 2024

MSI-H/dMMRAll Stages2024

Neoadjuvant Immunotherapy Alone for Patients With Locally Advanced and Resectable Metastatic Colorectal Cancer of dMMR/MSI-H Status.

Li Y et al. Dis Colon Rectum. 2024